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CARDIAC DRUG SIDE EFFECTS AND INTERACTIONS

1) Which group of drugs DECREASE the activity of warfarin
(All others INCREASE the activity of warfarin)
a) Simvistatin (Zocor), Lovastatin (Mevacor) - but not pravastatin or atorvastatin
b) Fluconazole (Diflucan), miconazole
c) Cimetidine (Tagamet) - but not other H2 blockers
d) Flagyl, Bactrim, Biaxin, Cipro, Levaquin
e) Amiodarone, Propafenone (Rythmol), Alcohol
f) Colestyramine (Questran), Colestipol, Sucralfate (Carafate), Tegretol, St. John’s Wort

2) Which antidepressants can increase the levels of beta-blockers (Coreg, Lopressor) potentially leading to bradycardia/hypotension
a) Prozac, Paxil
b) Zoloft, Effexor
c) Luvox, Serzone
d) Celexa

3) Which antidepressants can increase the levels of all Ca-channel blockers potentially leading to bradycardia/hypotension
a) Prozac, Paxil
b) Zoloft, Effexor
c) Luvox, Serzone
d) Celexa

4) Which antidepressants can increase the levels of Zocor and Mevacor - but not Pravacol, Crestor, Lescol, Lipitor - increasing risk of myopathy/rhabdo/renal failure
a) Prozac, Paxil
b) Zoloft, Effexor
c) Luvox, Serzone
d) Celexa

5)Which can be associated with 2 to 4 fold increases in digoxin levels
a) Verapamil, Cardizem
b) Amiodarone, Propafenone
c) Quinidine
d) Erythromycin, Biaxin, Zithromax
e) all of above
f) none of above

Answers at bottom of page

ANSWERS: f, a, c, c, e

CARDIAC DRUG SIDE EFFECTS AND INTERACTIONS

1) Which group of drugs DECREASE the activity of warfarin (All others INCREASE the activity of warfarin)
a) Simvistatin (Zocor), Lovastatin (Mevacor) - but not pravastatin or atorvastatin
b) Fluconazole (Diflucan), miconazole
c) Cimetidine (Tagamet) - but not other H2 blockers
d) Flagyl, Bactrim, Biaxin, Cipro, Levaquin
e) Amiodarone, Propafenone (Rythmol), Alcohol
f) Colestyramine (Questran), Colestipol, Sucralfate (Carafate), Tegretol, St. John’s Wort

2) Which antidepressants can increase the levels of beta-blockers (Coreg, Lopressor) potentially leading to
  bradycardia/hypotension
a) Prozac, Paxil
b) Zoloft, Effexor
c) Luvox, Serzone
d) Celexa

3) Which antidepressants can increase the levels of all Ca-channel blockers potentially leading to
  bradycardia/hypotension
a) Prozac, Paxil
b) Zoloft, Effexor
c) Luvox, Serzone
d) Celexa

4) Which antidepressants can increase the levels of Zocor and Mevacor - but not Pravacol, Crestor, Lescol, Lipitor   - increasing the risk of myopathy/rhabdo/renal failure
a) Prozac, Paxil
b) Zoloft, Effexor
c) Luvox, Serzone
d) Celexa

5) Which can be associated with 2 to 4 fold increases in digoxin levels
a) Verapamil, Cardizem
b) Amiodarone, Propafenone
c) Quinidine
d) Erythromycin, Biaxin, Zithromax
e) all of above
f) none of above   GO TO BOARD REVIEW QUIZZES FOR ANSWERS
 

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