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EvidenceMedicine.com / GuidelineMedicine.com
MedLine Plus Drug Info Medline Plus Drug Info (free, no password) suitable for doctors and patients
PDR www.pdr.net (requires password/account)
Merck Medicius www.merckmedicus.com (requires password/account for free access to many established resources, sponsored by a pharmaceutical company)
FREE PDA DOWNLOAD: ePOCRATES DRUG REFERENCE http://www2.epocrates.com/products/rx6_51.html
FDA BLACK BOX WARNINGS:
SEREVENT: http://www.fda.gov/medwatch/SAFETY/2003/serevent_PI.pdf
SERZONE: http://www.fda.gov/medwatch/SAFETY/2002/serzone_deardoc.PDF
ANTIDEPRESSANTS: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/psn/printer.cfm?id=275
DOXORUBICIN: http://www.fda.gov/cder/foi/appletter/2002/50467slr064,067,50629slr010,013ltr.pdf
SEROQUEL: http://www.fda.gov/cder/drug/InfoSheets/HCP/quetiapineHCP.pdf
DEPO-PROVERA: http://www.fda.gov/bbs/topics/ANSWERS/2004/ANS01325.html
NEUTREXIN: http://www.fda.gov/cder/foi/label/2002/20326s11s13lbl.pdf
FDA RECALLS AND SAFETY ALERTS: http://www.fda.gov/opacom/7alerts.html
LOVENOX SAFETY ALERTs
2004 WARNINGS RELATED TO RENAL IMPAIRMENT AND SPINAL/EPIDURAL ANESTHESIA
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/psn/printer.cfm?id=270
(2002) “Prosthetic Heart Valves: The use of Lovenox Injection is not recommended for thromboprophylaxis in patients with prosthetic heart valves. Cases of prosthetic heart valve thrombosis have been reported in patients with prosthetic valves who have received enoxaparin for thromboprophylaxis. Some of these cases were pregnant women in whom thrombosis led to maternal deaths and fetal deaths. Pregnant women with prosthetic heart valves may be at higher risk for thromboembolism” http://www.fda.gov/medwatch/SAFETY/2002/lovenox.htm
From WebMD: “Alleve Alert” (Dec 2004) http://my.webmd.com/content/pages/20/104890.htm?z=1728_ 00000_1000_sl_01
“The over-the-counter drug Aleve, sold generically as naproxen, joins the list of recent painkillers facing federal scrutiny for potential heart risks. The National Institutes of Health has suspended an Alzheimer's prevention trial involving Aleve and Celebrex, because Aleve was shown to increase the risk of heart attacks or stroke by 50% among healthy elderly patients”
“Pfizer Finds Celebrex Heart Attack Risk” (AP/ATT,12-17)
“NEW YORK (AP) - Pfizer Inc. said it found an increased risk of heart attacks for patients taking high dosages of its top-selling painkiller Celebrex, the same problem that led to the withdrawal of its one-time competitor Vioxx.
The company said it has no plans to remove Celebrex from the market, but the disclosure on Friday sent Pfizer's shares tumbling because of fears that it could cripple sales of what had been the most-prescribed drug for treating arthritis.”
http://dailynews.att.net/cgi-bin/news?e=pri&dt=041217&cat=ne ws&st=newsd871kuc80&src=ap
“FDA Failed Public on Vioxx - - Scientist” (Reuters/NYTimes, 11-19-04)
http://www.nytimes.com/reuters/news/news-health-merck.html?oref=login
“Graham named five medicines currently on the market that he believes need closer scrutiny for safety: Abbott Laboratories Inc.'s (ABT.N) weight-loss drug Meridia, AstraZeneca Plc's (AZN.L) cholesterol-lowering drug Crestor, Pfizer Inc.'s (PFE.N) painkiller Bextra, Roche's (ROG.VX) acne drug Accutane, and GlaxoSmithKline Plc's (GSK.L) asthma drug Serevent.”
DRUG ALERT (9-30):
MERCK PULLS VIOXX FROM U.S. MARKET
http://www.cnn.com/2004/HEALTH/09/30/vioxx.with drawn.reut/index.html
“The arthritis drug Vioxx, used by millions of people around the world, is being pulled off the market after a study confirmed long-standing concerns that it raises the risk of heart attack and stroke, the manufacturer, Merck & Co., said today.” (cnn, 9-30)
“Oral Erythromycin and the Risk of Sudden Death from Cardiac Causes”
http://content.nejm.org/cgi/content/short/351/11/1089
“The adjusted rate of sudden death from cardiac causes was five times as high (incidence-rate ratio, 5.35; 95 percent confidence interval, 1.72 to 16.64; P=0.004) among those who concurrently used CYP3A inhibitors and erythromycin as that among those who had used neither CYP3A inhibitors nor any of the study antibiotic medications”
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